Select a class of APIs and select a formulation strategy to enable these APIs to be developed into medicines: Phase Appropriateness Essay, UCD, Ireland

Select a class of APIs and select a formulation strategy to enable these APIs to be developed into medicines. Pretend you are the first one to come up with this idea. You can pick anything – e.g. long-acting injectable suspensions or cocrystallization for poorly water-soluble APIs, a metal-organic framework for controlled release of APIs, pegylation for therapeutic proteins, etc. If based on an existing idea/core paper, please cite the paper at the very start of the assignment.

• Outline the issue/problem that your new formulation idea will resolve. Explain what your idea is and how it will work. Indicate what type of API and/or routes of administration it will be useful for.
• Describe how your idea is better than other formulation strategies that exist and the impact it could have in the world.
• Outline the experiments that you would do to prove your idea would work over a period of 4 years.

1. Select examples of APIs you would test and excipients you would use and give a rationale for your selection.
2. Describe the actual experiments and methods you would do.
3. Describe the analysis you would do to determine if your formulation had worked – include the analytical equipment you would use for the characterization of your formulation.

• Estimate the budget you would need to work on this idea for 4 years.
• Describe the outputs you would generate at the end of the 4 years.